While most of The Children's Guild's students have multiple emotional and behavioral disabilities, the organization has found within its population a subset of students who also have multiple sensory needs and autistic-like behaviors. These students benefit from an individualized, structured teaching environment and curriculum.

The Children's Guild's autism spectrum program utilizes The TEACCH approach, used to educate students in a structured learning environment.
 
The Children's Guild approaches each student on an individual basis according to his or her communication skills and cognitive level. Students are taught to be mindful of and responsible for their actions. Most importantly, students become aware of their strengths, weaknesses, and personal and vocational goals.

Classes for children with autism spectrum are provided at both Children's Guild campuses. In Baltimore, the program is connected to the school-to-work vocational training program, which serves students ages 14 to 21. The Prince George's day school campus programs serve children with autism and Asperger's Syndrome from kindergarten through eighth grade.